I think Kloxo is no longer being updated and may have a security issue or two.
There is not a single panel that can manage both Linux and Windows servers at the same time that I know of.
I recently spent a day playing with ISPConfig. Its a nice panel to ride on a Linux machine. Seems to work perfect with CentOS, and it can be set-up to manage multiple servers at multiple hosts from one panel. I'm speaking of dedicated machines (not VPS).
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