Decide your demography (For example in Germany, Netload is the best)
Decide your plan: PPS or PPD (For PPs, FSC is the best. Always upload large size files, urge downloaders to buy premium
If you use mirrors, choose PPD.
For PPD and reputation, you should use at least one of Rapidshare and Megaupload.
Proffessionals always have a nieche: Prefer one area: tv shows-movie-music-game-
Use both for now .file host: undecided between filesonic and fileserve.
90% are starting with movies , but beware of fake releases .area: games, movies, series.