The difference is you will need to write MUCH less code with C# compared to C and C++, but you are also rather limited compared to them.
You have google for hidden apis and judging from the fact thet programming is the mother of the internet probably you'll find more programming sites then porn ones.its limiting in that lots of C APIs arent exposed, like global hotkeys etc.
What do you mean with "C# and .NET" exactly? C# is using the .NET Framework, C and C++ are not :P
:P